Pre-implantation genetic screening (PGS) is a technique that helps identify genetic abnormalities in embryos before implantation. It is an advanced technology that helps improve the chances of having a healthy baby.

PGS is a popular technique used in in-vitro fertilization (IVF) and has proven to be effective in preventing genetic diseases and disorders. This article discusses the different techniques used in PGS and how they help improve the chances of having a successful pregnancy.

Understanding PGS

PGS is a technique used to screen embryos for genetic abnormalities before they are implanted in the uterus. It is carried out during IVF treatment, where eggs are fertilized in the laboratory and allowed to develop into embryos.

The embryos are then screened for genetic abnormalities before being transferred to the uterus. PGS helps identify embryos with chromosomal abnormalities and reduces the risk of implantation failure, miscarriage, and genetic disorders in the offspring.

Techniques Used in PGS

Fluorescence In Situ Hybridization (FISH)

FISH is a technique used in PGS to detect chromosomal abnormalities in embryos. It involves fluorescently labeled probes that bind to specific sequences of DNA on chromosomes.

The fluorescent signals are then analyzed under a microscope to determine the number and structure of chromosomes in the embryo. FISH is a widely used technique in PGS, but it has several limitations and may not be effective in detecting all chromosomal abnormalities.

Comparative Genomic Hybridization (CGH)

CGH is a more advanced technique used in PGS to detect chromosomal abnormalities in embryos. It involves the analysis of the entire genome of the embryo to detect any changes in the number or structure of chromosomes.

CGH is a more comprehensive technique than FISH and can detect all types of chromosomal abnormalities. It has a higher accuracy rate than FISH and is preferred for PGS in most cases.

Next-Generation Sequencing (NGS)

NGS is the latest technique used in PGS to detect chromosomal abnormalities in embryos. It involves the analysis of the entire genome of the embryo using advanced sequencing technology.

NGS is a more comprehensive and accurate technique and can detect all types of chromosomal abnormalities. It is less time-consuming than CGH and is becoming more popular for PGS.

Benefits of PGS

PGS has several benefits that make it a popular technique in IVF treatment. Some of the benefits of PGS include:.

Reduced risk of implantation failure and miscarriage
Reduced risk of having a child with genetic disorders
Improved chances of having a healthy baby
Reduced need for multiple embryo transfers
Reduced cost of IVF treatment due to fewer cycles

Conclusion

PGS is a miraculous technique used to detect chromosomal abnormalities in embryos before implantation. It is an effective way to reduce the risk of implantation failure, miscarriage, and genetic disorders in the offspring.

PGS is carried out using different techniques such as FISH, CGH, and NGS, each with its own advantages and limitations. PGS is a popular technique in IVF treatment, and it has several benefits that make it a preferred option for couples undergoing infertility treatment.