Diabetes has become one of the prevalent diseases in the world, with millions of people being diagnosed every year. Researchers have been working relentlessly to control diabetes and prevent its complications.

Swiss researchers have now made a groundbreaking discovery, controlling the diabetes “clock”.

What is the Diabetes “Clock”?

The “clock” referred to here is the circadian rhythm of the body. The body’s circadian rhythm is a 24-hour cycle that regulates functions such as sleep, hormone production, and metabolism.

This internal clock can be disrupted by factors such as jet lag, shift work, or lifestyle habits, affecting the body’s overall health.

In diabetic patients, circadian rhythm disruptions lead to poor blood sugar control, increased insulin resistance, and complications such as fatty liver disease.

Therefore, controlling the diabetes “clock” can improve glucose metabolism and prevent complications in these patients.

Swiss Scientists’ Research

Scientists at the University of Geneva have discovered a protein called Rev-erb alpha, which is responsible for regulating the circadian rhythm in the liver.

Rev-erb alpha acts as a “break” on the clock, slowing down the metabolic processes in the liver when necessary.

The researchers found that Rev-erb alpha also plays a role in glucose metabolism. By manipulating Rev-erb alpha levels in mice, the researchers were able to control the liver’s glucose production and improve insulin sensitivity.

The team also found that Rev-erb alpha levels are low in diabetic patients, leading to circadian rhythm disruptions and poor glucose metabolism.

However, by increasing Rev-erb alpha levels, the researchers were able to improve glucose metabolism in diabetic mice.

Implications of the Research

The discovery of Rev-erb alpha’s role in glucose metabolism and circadian rhythm regulation has significant implications for the treatment of diabetes.

By manipulating this protein, researchers may be able to prevent the disruptions in glucose metabolism that occur in diabetic patients and prevent complications such as fatty liver disease.

The researchers also believe that this discovery could lead to the development of new drugs that target Rev-erb alpha, providing a new avenue for the treatment of diabetes.

Conclusion

The research conducted by Swiss scientists at the University of Geneva has revealed a significant breakthrough in the field of diabetes treatment.

By controlling the diabetes “clock” through manipulating the protein Rev-erb alpha, researchers may be able to prevent complications in diabetic patients and develop new treatments for diabetes in the future.