Angelina Jolie has been one of the most iconic actresses of our generation. She’s starred in several blockbuster movies, has captured several hearts, and has an inspiring story of strength and perseverance.

Beyond her glamorous life on-screen, Angelina has been the subject of many headlines due to her family history of cancer and her own battles with the disease.

Angelina Jolie has publicly discussed her decision to have a preventive double mastectomy and her decision to have her ovaries removed to decrease her risk of cancer.

These surgeries were based on her genetic makeup and family history of cancer, and she decided to take preventative measures to manage her risk. However, Angelina’s story is not unique—many families have a long history of cancer, and it’s important to understand the genetic link behind it.

The Genetic Link Behind Familial Cancer

It’s common knowledge that cancer is caused by genetic mutations that occur within individual cells. These mutations cause abnormal cell growth and division, leading to the development of a malignant tumor.

However, not all cancers are the result of random mutations. Family history and genetics can play a significant role in the development of some cancers.

BRCA1 and BRCA2 are two genes that are responsible for preventing cancer. These genes are responsible for producing proteins that suppress tumor growth, and when they are mutated, the risk of cancer significantly increases.

Mutations in these genes are inherited, and individuals who carry these mutations have a higher risk of developing cancer.

Mutations in the BRCA genes are often linked to breast and ovarian cancers, but they can also increase the risk of other cancers, including male breast cancer and certain types of prostate cancer.

Approximately 5-10% of breast cancer cases and 10-15% of ovarian cancer cases are the result of inherited mutations in the BRCA genes.

Angelina Jolie’s Family History of Cancer

Angelina Jolie’s family history of cancer is well-known. Angelina’s mother, Marcheline Bertrand, was diagnosed with ovarian cancer at the age of 49 and died from the disease in 2007. Her grandmother, aunt, and cousin also died from cancer.

Angelina was particularly concerned about her risk of developing ovarian cancer due to her family history. Ovarian cancer often goes undetected until it has reached an advanced stage, making it difficult to treat.

Angelina underwent genetic testing and discovered that she carried a mutation in the BRCA1 gene, which significantly increased her risk of developing both breast and ovarian cancer.

Angelina Jolie’s Decision to Undergo Preventive Surgeries

After discovering that she carried a BRCA1 mutation, Angelina Jolie made the decision to undergo a preventive double mastectomy. This surgery involved removing both breasts to decrease her risk of developing breast cancer.

In 2015, Angelina also had her ovaries and fallopian tubes removed to decrease her risk of developing ovarian cancer.

While preventive surgeries do not completely eliminate the risk of cancer, they can significantly decrease an individual’s risk.

In Angelina’s case, the surgeries decreased her risk of developing breast cancer by up to 90% and her risk of developing ovarian cancer by up to 95%.

The Importance of Genetic Counseling and Testing

Angelina Jolie’s decision to undergo genetic testing and to manage her risk of cancer through preventive surgeries is an inspiring story of strength and empowerment.

However, it’s important to note that preventive surgeries are not the right choice for everyone.

Genetic testing can be a useful tool for individuals with a family history of cancer to determine their risk and make informed decisions about their health.

Genetic counseling can also be beneficial in helping individuals understand their results and make decisions about their healthcare.

Angelina Jolie’s Impact on Awareness and Research

Angelina Jolie’s decision to speak openly about her experience with cancer has had a significant impact on raising awareness about the importance of genetic testing and preventive healthcare measures.

Her work has also helped to advance research and treatment options for individuals with a genetic risk of cancer.

Angelina Jolie’s story is a reminder of the importance of family history and genetics in cancer prevention.

Understanding your risk and making informed decisions about your healthcare can help to reduce your risk and lead to better health outcomes.

The Bottom Line

Angelina Jolie’s story has shed light on the genetic link behind familial cancers. Mutations in genes such as BRCA1 and BRCA2 can significantly increase an individual’s risk of developing certain types of cancer.

Genetic testing and counseling can be a useful tool for individuals with a family history of cancer to determine their risk and make informed decisions about their healthcare.

Angelina Jolie’s decision to undergo preventive surgeries has had a significant impact on raising awareness about the importance of taking preventive measures to manage the risk of cancer.

Her story is a reminder that understanding your risk and making informed decisions about your healthcare can help to lead to better health outcomes.