Itchy skin is a common occurrence that can happen to anyone at any time, but when itching specifically occurs in the evening, it may be a sign of an underlying serious illness or condition.

While most cases of itching in the evening are harmless and can be attributed to dry skin, allergies, or insect bites, it is important to be aware of the potential causes that may require medical attention. In this article, we will explore some of the serious illnesses that can cause itching in the evening and discuss their symptoms, diagnosis, and treatment options.

1. Liver Disease

One of the conditions associated with itching in the evening is liver disease. In liver diseases like cirrhosis or hepatitis C, the organ’s ability to filter toxins from the blood is compromised, leading to a buildup that can cause itching.

This itching is often worse at night because toxins tend to accumulate during the day, and the body’s natural detoxification process intensifies at night, leading to increased itching.

2. Kidney Disease

Another potential cause of itching in the evening is kidney disease. When the kidneys are not functioning properly, waste and toxins can accumulate in the body, resulting in itching.

Kidney disease-related itching can be particularly intense at night, as kidney function fluctuates throughout the day. Additionally, mineral imbalances and hormonal changes associated with kidney disease can contribute to itchiness.

3. Lymphoma

Lymphoma is a type of cancer that affects the lymphatic system, which plays a crucial role in the body’s immune response. In some cases, lymphoma can cause itching, especially in the evening.

Although the exact reasons behind itchiness in lymphoma are not fully understood, it is believed to be related to the release of certain chemical substances by the cancer cells.

4. Leukemia

Leukemia is a type of blood cancer that affects the bone marrow and disrupts the normal production of blood cells, including white blood cells. Itching can be one of the symptoms of leukemia, particularly in the evening.

It is thought to be caused by the buildup of leukemic cells in the skin, which release certain substances triggering the itching sensation.

5. Diabetes

Persistent itching, especially at night, can be an early warning sign of diabetes. Diabetes affects the body’s ability to regulate blood sugar levels properly. High blood sugar levels can lead to dry skin and make it more prone to itchiness.

Additionally, diabetes can also cause nerve damage, leading to a condition called diabetic neuropathy, which can cause itchiness.

6. Thyroid Conditions

Various thyroid conditions such as hypothyroidism or hyperthyroidism can be associated with itching in the evening. In these conditions, the thyroid gland does not produce enough or produces excessive amounts of hormones, respectively.

Hormonal imbalances can affect the skin, leading to dryness, flakiness, and itching.

7. Iron Deficiency Anemia

Iron deficiency anemia occurs when the body lacks sufficient iron to produce an adequate amount of red blood cells. Itchy skin, particularly in the evening, can be a symptom of this condition.

Anemia-related itching is not fully understood, but it is believed to be associated with the reduced oxygen supply to the skin.

8. Autoimmune Diseases

Several autoimmune diseases, such as lupus or psoriasis, can cause itching, including itching in the evening. In autoimmune diseases, the immune system mistakenly attacks healthy cells, leading to inflammation and skin-related symptoms.

Itching can be a result of the skin’s reaction to the immune system dysfunction.

9. Gallbladder Issues

Gallbladder problems, such as gallstones or inflammation of the gallbladder (cholecystitis), can sometimes cause itching in the evening.

The exact reason behind this is not fully understood, but it is believed to be related to the release of certain substances or changes in bile composition that affect the skin.

10. Medications or Allergies

Lastly, some medications or allergic reactions can cause itching, including evening itching. Certain drugs, such as opioids, antifungals, or antibiotics, can have itching as a side effect.

Additionally, allergies, either seasonal or triggered by certain foods or substances, can cause itching in the evening and should be considered as a potential cause.

If you experience persistent itching in the evening or any associated symptoms, it is crucial to consult with a healthcare professional to determine the underlying cause and receive appropriate treatment.

Self-diagnosis is not recommended, as these symptoms can also be attributed to other non-serious conditions.